Abstract
The present study discloses the synthesis of certain sulfathiazole-triazole hybrids. Versatile sulfonamide derivatives were unexpectedly obtained during the course of synthesis upon treatment with various amounts of hydrazine hydrate, throughout either ring-cleavage or complete detachment of the thiazole moiety. Assorted hydrazide intermediates were obtained, and utilized to form a diversity of sulfonamide-based scaffolds, tagged with triazole and hydrazone/pyrazole functionalities, aiming to be further investigated for cytotoxic activity. All the synthesized compounds were characterized by 1H-NMR and 13C-NMR.
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