Abstract
AbstractThe associations that have been noted between the clinical use of the thiazide diuretics and impairment of male sexual performance remain enigmatic. Recent studies are reviewed, in which aspects of the male sexual dysfunction in hypertensive men following treatment with thiazide diuretics were examined. The data are interpreted in light of previously published studies on the subject to suggest that penile erectile defects and decrements in sexual activities are specifically related to thiazide administration. A rodent model of thiazideinduced male sexual dysfunction is introduced that documents dose‐related impairment, by hydrochlorothiazide, of penile erectile reflexes and male copulatory performance. The etiology of thiazide‐induced male sexual dysfunction is hypothesized to result from alterations in sodium excretion that alter afferent renal nerve input to hypothalamic areas regulating male sexual responses.
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