Abstract
Experiments for investigating thiamine metabolism in magnesium-deficient rats were carried out, and the following results were obtained. 1. Thiamine concentration in the sciatic nerve, liver, heart, and kidneys of magnesium-deficient rats was lower than that in the magnesium-sufficient rats. A decrease in thiamine was not detected in the central nervous system of magnesium-deficient rats. 2. In subcellular fractions of the liver of magnesium-deficient rats, thiamine content was most markedly decreased in the mitochondrial fraction. 3. When thiamine-14C was administered to magnesium-deficient rats, radioactivity in 24-hour urine decreased, and the radioactivity in the blood, liver, kidneys, heart, and sciatic nerve increased as compared to magnesium-sufficient rats. 4. With either oral or parenteral administration of thiamine, thiamine content in the heart, liver, and kidneys decreased at the same level in magnesium-deficient rats. A plausible mechanism is suggested by these results.
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