Abstract
Cancer is a general name for a group of more than 100 diseases in which cells belonging to a part of the body, begin uncontrolled proliferation. Nowadays, cancer is an important public health problem in all countries. For decades, conventional chemotherapy has been the most common type of anticancer pharmacotherapy. Cancer chemotherapy has been one of the major advances in the field of medicine in the last few decades. However, drugs administered for chemotherapy have a narrow therapeutic index and therefore, there is a high incidence of unwanted side effects. Thiadiazole is a five-membered ring system that has gained prominence by exhibiting a wide variety of biological activities. It has interesting pharmacophores that display a broad spectrum biological activity. The lower toxicity and in vivo stability of 1,3,4-thiadiazole nucleus are attributed to its aromaticity. Thiadiazole has exhibited potential antiglaucoma, antiinflammatory, antitumor, antiulcer, antibacterial, antiviral, analgesic, antiepileptic, antifungal and radioprotective activities. In this review article antitumor activity of various thiadiazole derivatives has been discussed.
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