Abstract
Thiabendazole, when used in doses of 50 mg/kg daily for two days or 25 mg/kg/b.i.d for two days permanently stops the activity of over 99% of the larvae on the first day of therapy. The series is still small enough to make it difficult to evaluate the various dosage schedules for their relative incidence of side effects. Probably the least side effects will occur with 25 mg/kg twice daily for two days. The side effects apparently result from a central nervous system effect of the drug. Dizziness precedes any nausea or vomiting. The patients who vomited still had excellent therapeutic results. To date, the side effects were not a serious enough handicap to limit the use of the drug. The limitations of applicability of in vitro testing with nematode larvae are discussed.
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