Abstract
parametric multipoint LOD score was at the marker D13S779 (LOD=1.5, p=0.004). On chromosome Xq, evidence for linkage was observed across a large region spanning two regions previously linked to bipolar disorder; Xq24 to Xq28, with a peak at marker TTTA062 (LOD 2.10, p=0.0009) in Xq28. Results for these regions exceed the recommended p-value for a replication study of pb0.01 and thus provide evidence for these two loci as contributing to mood disorders with juvenile onset. Discussion: Our genome scan of juvenile-onset mood disorders points to 2 chromosomal regions previously identified as linked to bipolar disorder supporting continuity for child and adult genetic risks at least for these two loci.
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