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Abstract
Theta (6–12 Hz) rhythmicity in the local field potential (LFP) reflects a clocking mechanism that brings physically isolated neurons together in time, allowing for the integration and segregation of distributed cell assemblies. Variation in the theta signal has been linked to locomotor speed, sensorimotor integration as well as cognitive processing. Previously, we have characterized the relationship between locomotor speed and theta power and how that relationship varies across the septotemporal (long) axis of the hippocampus (HPC). The current study investigated the relationship between whole body acceleration, deceleration and theta indices at CA1 and dentate gyrus (DG) sites along the septotemporal axis of the HPC in rats. Results indicate that whole body acceleration and deceleration predicts a significant amount of variability in the theta signal beyond variation in locomotor speed. Furthermore, deceleration was more predictive of variation in theta amplitude as compared to acceleration as rats traversed a linear track. Such findings highlight key variables that systematically predict the variability in the theta signal across the long axis of the HPC. A better understanding of the relative contribution of these quantifiable variables and their variation as a function of experience and environmental conditions should facilitate our understanding of the relationship between theta and sensorimotor/cognitive functions.
Highlights
The laminar organization of the hippocampus (HPC) provides an optimal architecture for the generation of local field potentials (LFPs) such as theta or sharp waves [1,2,3]
The relationship between acceleration/deceleration and theta amplitude is shown as a function of distinct speed categories (0–25 cm/s; .25–50 cm/s; .50 cm/s; Fig. 1E) and evidences a possible interaction between speed and acceleration such that the relationship between theta amplitude and acceleration appears to be maximal at low speeds (, = 25 cm/s) whereas the relationship between deceleration and theta amplitude is maximal at high speeds (.50 cm/s)
Summary Overall these data suggest that there was a differential relationship between theta amplitude and acceleration/deceleration, with deceleration explaining more of the variability in theta amplitude as compared to acceleration over and above the influence of locomotor speed
Summary
The laminar organization of the hippocampus (HPC) provides an optimal architecture for the generation of local field potentials (LFPs) such as theta or sharp waves [1,2,3]. These LFP signals reflect the summation of local excitatory and inhibitory synaptic potentials impinging upon the somatodendtric field of hippocampal neurons. Recent findings have highlighted significant variation in the amplitude and coherence of the theta signal across the septotemporal, areal or long axis of the HPC [27,28,29,30]. The latter is consistent with a large literature detailing functional and anatomical variation across the longitudinal (anteroposterior in humans) axis [31]
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