Abstract
MICE homozygous for the mutation nude (nu/nu) are hairless1 and deficient in thymus2–4 and thymus-derived (T)5,6 lymphocytes. They are generally referred to as being athymic and are widely used in immunology as a source of B lymphocytes uncontaminated with T cells, although there is evidence that the thymus is present, but is small and dysplastic3,4. Indirect evidence has suggested that at least some nude mice have small numbers of T cells7–9, but this has been controversial. I report here the direct demonstration by immunofluorescence of a small population of θ-bearing cells in lymph nodes and spleens of nude mice using fluorescein-conjugated anti-θ antibody.
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