Abstract

Low-frequency oscillations are supposed to drive the binding of information across a large-scale network centered on the hippocampus, which supports mnemonic functions. The electrophysiological means to investigate this phenomenon in humans (EEG/MEG), however, are inherently limited by their spatial resolution and therefore do not allow a precise localization of the brain regions involved. By combining EEG with BOLD-derived estimates of hippocampal connectivity during recognition, we can identify the striatum and specific areas in the medial and lateral PFC as part of a circuit linked to low-frequency oscillations (4-13 Hz) that promotes hippocampus-dependent context retrieval. Therefore, the current study closes an apparent gap in our understanding of the network dynamics of memory retrieval.

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