Abstract
Thermosensitive poly(organophosphazenes) were synthesized for a controlled release of hydrophilic polymeric model drugs such as dextran and albumin in this study. The solutions of the present polymers bearing both hydrophobic side groups of l-isoleucine ethyl ester (IleOEt) and hydrophilic groups of α-amino-ω-methoxy-PEG ( M w 550) (AMPEG550) exhibited reversible sol–gel transition behaviors with changes of temperature. Viscometric measurement indicated that the thermosensitive hydrogels with good strength could be formed from the solutions in the range of the concentrations of 7–15 wt% around body temperature. For increasing their biodegradabililites, depsipeptides of ethyl-2-( O-glycyl)lactate (GlyLacOEt) were also introduced to the polymer, showing enhanced degradation of hydrogels. In vitro release behaviors of hydrophilic FITC-dextran ( M w 71,600) and human serum albumin from these polymer hydrogels were sustained for about 2 weeks while those from poloxamer (Pluronic F-127) hydrogel showed a distinct initial burst. The release of FITC-dextran exhibited concentration-dependent behavior ranging from 7 to 15 wt% of the polymer solution while it was almost independent of the concentration of FITC-dextran.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: European Journal of Pharmaceutics and Biopharmaceutics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
