Abstract
Today, with the advances in technology and science, more advanced drug delivery formulations are required. One of these new systems is an intelligent hydrogel. These systems are affected by the environment or conditions that become a gel, stay in the circumstance for a certain period, and slowly release the drug. As an advantage, only a lower dose of the drug is required, and it provides less toxicity and minor damage to other tissues. Hydrogels are of different types, including temperature-sensitive, pH-sensitive, ion change-sensitive, and magnetic field-sensitive. In this study, we investigated a kind of temperature-sensitive smart hydrogel, which has a liquid form at room temperature and becomes gel with increasing temperature. Chitosan-β-glycerophosphate hydrogels have been researched and used in many studies. This study investigates the various factors that influence the gelation mechanism, such as gel formation rates, temperature, pH, time, and gel specificity. Hydrogels are used in many drug delivery systems and diseases, including nasal drug delivery, vaginal drug delivery, wound healing, peritoneal adhesion, ophthalmic drug delivery, tissue engineering, and peptide and protein delivery. Overall, the chitosan-β-glycerophosphate hydrogel is a suitable drug carrier for a wide range of drugs. It shows little toxicity to the body, is biodegradable, and is compatible with other organs. This system can be used in different conditions and different medication ways, such as oral, nasal, and injection.
Highlights
Today, with the advances in technology and science, new pharmaceutical formulations have been investigated
A variety of temperature-sensitive hydrogel, chitosan-β-glycerophosphate, was investigated and evaluated. It has a liquid form at room temperature but becomes gel with an increase in temperature. is hydrogel can deliver a wide range of drugs
We investigate the various factors that influence the gelation mechanism [1, 2]
Summary
With the advances in technology and science, new pharmaceutical formulations have been investigated. One of the new types of systems is smart hydrogels, which become gel based on environmental factors or specific conditions, stay in place for a certain period, and slowly release the drug. In these systems, a certain amount of the drug is delivered to the target site, and other tissues are less damaged. A variety of temperature-sensitive hydrogel, chitosan-β-glycerophosphate, was investigated and evaluated It has a liquid form at room temperature but becomes gel with an increase in temperature. Networked hydrogels are soluble in water, which becomes gel due to changing environmental conditions such as temperature, pH, light, electric field, and ionic strength. Hydrogels can be swollen reversibly, and their swelling properties largely depend on their surroundings factors [7,8,9]. e temperature influences interactions between the hydrophilic and hydrophobic units with the water molecule. erefore, these changes can increase the solubility of the cross-linked network. is factor is the leading cause of the solid phase change from liquid to solid [10]. e change in the equilibrium between hydrophilicity and hydrophobicity determines the cross-links’ dissolution behaviour [11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
