Abstract
Abstract We describe, for the first time, a simple and one-pot fabrication of biocompatible hydrogels functioning as an elastin-like polypeptide (ELP) matrix in terms of thermoresponsibility and structure-proved bioavailability, without complicated pretreatment and synthesis. For this purpose, composite hydrogels were formed with a semi-IPN structure wherein untreated ELPs interpenetrated the alginate–Ca2+ hydrogel as the host three-dimensional network. These biocompatible and stimuli-responsive materials are highly useful as a novel injectable matrix to induce tissue differentiation after cellular encapsulation.
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