Abstract
Stimuli-responsive polymers have been widely studied in many applications such as biomedicine, nanotechnology, and catalysis. Temperature is one of the most commonly used external triggers, which can be highly controlled with excellent reversibility. Thermoresponsive polymers exhibiting a reversible phase transition in a controlled manner to temperature are a promising class of smart polymers that have been widely studied. The phase transition behavior can be tuned by polymer architectures, chain-end, and various functional groups. Particularly, thermoresponsive polypeptoid is a type of promising material that has drawn growing interest because of its excellent biocompatibility, biodegradability, and bioactivity. This paper summarizes the recent advances of thermoresponsive polypeptoids, including the synthetic methods and functional groups as well as their applications.
Highlights
Stimuli-responsive polymers that can undergo chemical or physical property changes as triggered by a variety of environmental stimuli have been extensively investigated because of their potential applications in the past few decades [1,2,3]
Transitions and observed that the phase transition of these polypeptoids can beinaffected by the pronounced hysteresis during the heating and cooling scans occurred the solutions of concentration, poly(N-propyl leading to various cp
We summarized the thermoresponsive polypeptoids including the synthetic techniques and functional groups, as well as their applications
Summary
Stimuli-responsive polymers that can undergo chemical or physical property changes as triggered by a variety of environmental stimuli have been extensively investigated because of their potential applications in the past few decades [1,2,3]. Post-polymerization modification that can incorporate hermoresponsive properties with tunable for highly biological or catalytic the pendant functional moieties has become a versatile synthetic approach to construct polymer activities withConsiderable thermoresponsivity [24] In nature, biomacromolecules such as protein and DNA offer a variety of design principles ynthetic materials to obtain biohybrid (macro)molecules that mimic proteins in their complexi for stimuli-responsive materials [25,26]. In contrast to the solid-phase method, the ROP approach offers an effective way to produce the polypeptoids with high molecular weights and large-scale yields [28,33,34] In this case, two distinct methods for preparation of functional polypeptoids have been reported including the controlled polymerization of functional monomer and post-polymerization modification (PPM) of well-defined polypeptoid precursors [35]. We will mainly discuss recent advances on the design and synthesis of thermoresponsive polypeptoids based on the ROP of NCA or NTA, as well as their biological applications
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