Abstract
Hyaluronic acid (HA) based thermo-responsive physical hydrogels were obtained through a one-pot functionalization of HA of different molar masses (from 38 to 990 kg mol−1) with thermo-responsive poly(2-isopropyl-2-oxazoline)-co-poly(2-n-butyl-2-oxazoline) (PiPrOx-co-PnBuOx) copolymers. The cloud point (Tcp) of PiPrOx-co-PnBuOxs varied according to their monomeric composition. The functionalized HA's thermo-responsiveness was characterised through rheology and UV–vis spectrophotometry. The hydrogel transition temperature could notably be modified in a controlled way by varying the comonomers ratio in the graft, with the crossing temperature of storage modulus G′ and loss modulus G″ being found to rise by about 1 °C when increasing the iPrOx unit content within the PiPrOx-co-PnBuOx grafted copolymer by 1% for a series of modified 990 kg mol−1 HA. The thermal transition of the material from room temperature to 37 °C was found out to be almost instantaneous, which is interesting for applications in injectable systems.
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