Thermoregulation, Not Just Camouflage: The Unique Vasculature of Giraffe Patches. A Cadaver Study with Clinical Implications.

Abstract

Serendipitously, a dead giraffe provided opportunity to study its vascular anatomy. Comparative animal studies have revealed important information for designing new flaps and new microsurgical techniques. So, do giraffe's patches support a thermal window concept, do animals with similar markings and habitat have a similar thermoregulatory role, and could results offer new insight into human thermoregulation and free tissue transfer? Previously described lead-oxide arterial-only injection studies, of a single giraffe, zebra, Africa wild dog, and spotted jaguar, all with wire-encircled pigmented patches; and archival human, pig, dog, cat, and rabbit studies, were compared. Each giraffe patch was supplied by just a single artery (angiosome) averaging 0.9 mm diameter, that divided near its center and sent dense, long, parallel, radiating spoke-wheel branches averaging 0.62 mm diameter to the patch margin, continuing as reduced-caliber choke anastomoses averaging 0.8 mm to link adjacent patch angiosomes. Uniquely arranged large veins, with an average of 1.66 mm, encircled the patches in the pale skin paralleled by arteriae comitantes averaging 0.22 mm. These arteries, connected to patch angiosomes, filled the veins intermittently by means of arteriovenous (A-V) shunts averaging 0.12 mm in diameter of magnitude never seen before in any species studied. None of the other three animals had angiosome territories matching their pigmented fur, or significant A-V filling. This study supports the "thermostatic" concept of the giraffe skin patches, with A-V shunts playing a major role. It affirms the need for further studies of these shunts in human thermoregulation and other flow regulations in physiology, pathology, and free tissue transfer.