Abstract
The rectal temperatures of mice held at 1, 27, and 38°C were determined immediately before and at several intervals following injection (ip) with parathion, carbaryl, and DDT. Whereas the rectal temperature was unchanged by DDT, there was a slight decrease in temperature of parathion-treated mice held at 1°C and a decrease in temperature of carbaryl-treated mice at all temperatures tested. A correlation was shown between cholinesterase inhibition and temperature decrease. Loss of thermoregulation in carbaryl-inhibited mice could be reduced by atropine at both low and high ambient temperatures. The LD 50 values of mice injected with parathion and carbaryl were significantly less at 1 and 38°C than at 27°C, whereas the LD50 of DDT-injected mice was unaltered by temperature.
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