Abstract
AbstractThe Sonogashira cross‐coupling reaction between aryl halides and terminal alkynes was carried out smoothly in water over a thermoregulated ligand–palladium catalyst under copper‐free conditions, resulting in good to excellent yields. The Sonogashira reaction was sensitive to the electronic nature of the substituents on the aryl halides. Aryl halides with an electron‐withdrawing group showed higher reactivity than those with an electron‐donating group. Particularly, this protocol could be applied to the synthesis of liquid crystals involving trans‐cyclohexyltolans. The products could be separated from the reaction system easily by decanting, and the catalyst was recovered in water and used directly for the next run.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
