Thermophysical Properties of Acetaminophen in Aqueous Solutions of Protic Ionic Liquids Based on Ethanolamine at T = 288.15–318.15 K

Abstract

Protic ionic liquids (PILs), a novel category of inexpensive and sustainable solvents, have been employed to solve industrial and medicine solubility problems. Using a combination of ultrasonic, volumetric, and electrical conductivity methods at 288.15–318.15 K and a pressure of ≈87.1 kPa, researchers investigated the thermophysical properties of acetaminophen (ACP) in water and aqueous solutions of three protic ionic liquids (PILs), which are composed of the cations 2-hydroxyethylammonium, bis(2-hydroxyethyl)ammonium, and tris(2-hydroxyethyl)ammonium as well as the anion lactate. Study of intermolecular interactions using the thermophysical properties is very important because it provides a deep insight into the forces that are functional in the liquid mixtures. For the medication acetaminophen in water and aqueous PIL solutions, thermophysical parameters including apparent molar volume and apparent molar isentropic compressibility are examined in the current work. The findings showed that interactions between acetaminophen and PILs predominated in the systems under study and that these interactions increased as the PIL concentrations rose. The positive transfer results have been interpreted using the cosphere overlap model.