Abstract
The paper presents the results of the development of a thermoelectric device in the form of a monocular dressing for contact cooling of the human eye through the eyelids. The developed device allows controlled local contact cooling of the eye structures through the eyelids and is designed to treat the acute and chronic eye diseases, reduce intraocular pressure, and reduce pain and inflammatory processes of the eye. The design features of the device and its technical characteristics are presented.
Highlights
Therapeutic hypothermia is a curative effect that involves reducing the patient's body temperature by forcing heat away from the surface of the body or internal organs to reduce the risk of ischemic tissue damage
Therapeutic hypothermia is successfully used in various fields of medicine in order to increase the resistance of brain cells to ischemia [2,3,4,5,6]
Lowering the temperature of the neurons of the central nervous system causes the development of metabolic depression in them, which leads to a decrease in oxygen consumption, increased resistance to hypoxia, ischemia and reperfusion [7, 8]
Summary
Therapeutic hypothermia is a curative effect that involves reducing the patient's body temperature by forcing heat away from the surface of the body or internal organs to reduce the risk of ischemic tissue damage. Therapeutic hypothermia in medicine has been known for over 200 years as an effective and proven method of neuroprotection in patients with some critical conditions, which reduces the mortality of patients and reduces the amount of damage to brain tissue. The following mechanisms of the neuroprotective action of therapeutic hypothermia are currently distinguished: inhibition of destructive enzymatic reactions; inhibition of free radical reactions; plasticity protection of lipoproteins of cytoplasmic membranes; reduced oxygen consumption in areas of the brain with low blood flow; improving oxygen delivery to the ischemic zones of the brain and reducing intracranial pressure; inhibition of biosynthesis and production of exitotoxic neurotransmitters [9,10,11,12]
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