Abstract
The thermodynamics of the interaction between the nanocluster iron-molybdenum Keplerate-type polyoxometalate {Mo72Fe30} and thiamine hydrochloride (vitamin B1) was studied. This system is considered as a model for new types of targeted drug delivery systems. We evaluated the thermodynamic characteristics of the interaction between {Mo72Fe30} and B1 using experimentally measured sorption parameters for methanol vapour and the enthalpy of the interaction with liquid methanol for the initial compounds ({Mo72Fe30}, B1) and the {Mo72Fe30}+B1 conjugate. It was determined that the energetically unfavourable interaction of the components is due to entropy's predominant contribution to the Gibbs energy. Using X-ray analysis, it was shown that the increase in entropy is associated with one of the components (thiamine hydrochloride) losing its crystal structure.
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