Abstract
The present work discusses the characteristics of solvation (Gibbs energy, enthalpic and entropic terms of Gibbs energy) for ketoprofen together with other nonsteroidal antiinflammatory drugs (NSAIDs) in aliphatic alcohols. Ketoprofen was studied by classical thermoanalytical methods of sublimation calorimetry, solution calorimetry, and solubility. Temperature dependence of the saturated vapor pressure was determined, and the sublimation enthalpy, ÎHsub0, and sublimation entropy, ÎSsub0, as well as their respective relative fractions in the total process were calculated. The parameters yielded for ketoprofen were compared with the respective literature data of other benzophenone derivatives. The Gibbs energy of solvation as well as enthalpic and entropic terms thereof in aliphatic alcohols were also studied for ketoprofen and compared with the properties of model substances and other NSAIDs (benzoic acid, diflunisal, flurbiprofen, and naproxen). In all cases, the major driving force of the solvation process is enthalpy. Correlations were derived between Gibbs energy of solvation in octanol, ÎGsolvoct, and the transfer Gibbs energy from water to octanol, ÎGtr0. Š 2003 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 92:2502â2511, 2003
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
