Abstract
The behaviour of functional groups having differing physicochemical characteristics have been examined in reversed-phase high performance liquid-solid chromatography using aqueous methanolic eluents. The effects of temperature, mobile phase organic modifier concentration and stationary phase on extrathermodynamic group values have been determined. Results fit into the framework of solvophobic theory with extrapolated group parameters being related to other extrathermodynamic terms. Group values exhibit linear enthalpy-entropy compensation behaviour as examined using ΔH-ΔG coordinates. A unique relationship between solute retention and the enthalpy of transfer for all solutes and phase systems examined is exhibited, and the overall study indicates that attempts to relate chromatographic retention data to drug liquid-liquid distribution is thermodynamically valid.
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