Thermodynamics of Formation of Molecular Complexes of Aromatic Nitro Derivatives with Lincomycin and β-Glycyrrhizic Acid

Abstract

It was found that lincomycin and β-glycyrrhizic acid form 1:2 molecular complexes with aromatic nitro derivatives. Quantum-chemical calculations of lincomycin and β-glycyrrhizic acid were performed. These compounds form a cavity and, like podands, are capable of accommodating guest molecules. The formation constants and the thermodynamic characteristics of the complexes were calculated. A linear correlation was found between the formation constants of the molecular complexes of β-glycyrrhizic acid and the Hammett constants of the substituents in the nitro derivatives. The complexes of lincomycin and β-glycyrrhizic acid with aromatic nitro derivatives are formed by a common mechanism involving related bonds.