Abstract
In transient phenomena, nature seems to prefer the pass of the maximum rate of reaction. The principle is called by Lord Rayleigh the principle of the least dissipation of energy. The other aspect of this principle is the equilibrium of the second coordinate. It is a very important law of nature and might be called the fourth law of thermo-dynamics. The most important meaning of this principle is seen in the application to the bio-physics. Foundation of this principle is endeavoured in the following.
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