Thermodynamic Study of Phenyl Salicylate Solutions in Aprotic Solvents at Different Temperatures

Abstract

Phenyl salicylate is employed as a nervous system depressant as well as an intestinal antiseptic owing to its antibacterial activity upon hydrolysis in the small intestine. Various partial molar quantities, namely, apparent molar volume (V Φ ), partial molar volume (V° m ), thermal expansion coefficient (α 2 ), and (∂ 2 V° m /∂T 2 ), of phenyl salicylate in aprotic solvents, i.e., acetonitrile, dimethyl sulfoxide, tetrahydrofuran, and 1,4-dioxane, at T = (293.15 to 313.15) K have been determined. The density and viscosity data were obtained with the help of a vibrating-tube densimeter and viscometer in a concentrarion range of (9.6·10 -3 to 33.0·10 -3 ) mol·kg -1 . The viscosity data have been analyzed using the Jones-Dole equation and the derived parameter B has also been interpreted in terms of solute-solvent interactions.