Abstract

AbstractThe interaction between poly(A) · poly(U) duplex and dyes (proflavine (PF) and 9‐aminoacridine (9‐AA)) was studied by means of the heat of mixing. From the results, thermodynamic quantities of poly(A) · poly(U) duplex‐dye systems for the intercalation process were estimated. The free energy change for the poly(A) · poly(U) duplex‐(PF) system is smaller than that for the poly(A) · poly(U) duplex‐(9‐AA) system, indicating that PF intercalated into poly(A) · poly(U) duplex is more stable than the intercalated 9‐AA. This conclusion is based on the absolute value of the heat of interaction between PF and poly(A) · poly(U) duplex being larger than that between 9‐AA and the poly(A) · poly(U) duplex.

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