Abstract
Transferases formally couple together two oxidoreductase reactions or two hydrolase reactions. Therefore the thermodynamic properties of transferase reactions can be calculated from differences between thermodynamic properties of two oxidoreductase or two hydrolase reactions. Ligases couple together two hydrolase reactions, and so their thermodynamic properties can be calculated from differences between two hydrolase reactions. These relationships are demonstrated by calculating standard transformed Gibbs energies of reaction and the changes in binding of hydrogen ions at pHs 5-9 of a number of oxidoreductase, transferase, hydrolase, and ligase reactions by use of the data base BasicBiochemData2 and its recent extensions. Coupling is not restricted to two reactions, and an example is given of the coupling of three reactions.
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