Thermodynamic properties of aqueous PEO–PPO–PEO micelles with added methylparaben determined by differential scanning calorimetry

Abstract

DSC experiments were performed on aqueous solutions of PEO–PPO–PEO (P105) amphiphiles in the low concentration regime (0–1%) to resolve the critical micelle concentration (cmc) both neat and co-formulated with methylparaben (MP). Further work was done at 10% amphiphilic copolymer concentrations and co-formulated with MP to resolve the variations in enthalpy. The compensation temperature, Tcompensation, was determined from the analyses for neat P105 as 293.9K; adding MP raises this to 328.43K.