Abstract
Purpose: To developing a simple, rapid and reliable analytical method for loratadine based on charge transfer complexation with chloranilic acid. Methods: The complex between loratadine and the complexing agent, chloranilic acid, was formed by mixing appropriate volumes of their solutions in non-aqueous media. Some features of the formed complex, such as molar ratio of the reaction and effect of time, were determined spectrophotometrically. Thermodynamic parameters were determined as well, the method was utilized in the assay of the drug in both bulk and tablet dosage forms. Results: The complex showed a wavelength of maximum absorption (λmax) at 527 nm (λmax of loratadine alone was 440 nm). Beer’s law was obeyed in the concentration range of 3.2 - 28.8 mg% (r 2 = 0.9997). The stoichiometry of the complex was 2:1 (loratadine: chloranilic acid) and the complex was stable for over 60 min. Thermodynamic results show that as temperature changed from 30 to 70 °C, enthalpy change (∆H) was steady at -0.254 kcal.mol -1 while the free energy (∆G) changed from -3.904 to -4.450 kcal.mol -1 . The complex appeared to be more stable at the slightly elevated temperature of 50 °C with a value of 757.14 mol -1 . Analysis of the drug in both bulk and dosage forms showed good accuracy and precision with recovery ranging from 99.98 ± 1.00 to 100.94 ± 2.39 %. Conclusion: Charge transfer complexation method with chloranilic acid was successfully developed for the simple, rapid and accurate determination of loratadine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.