Abstract
Studies on the interaction of cholesterol (CHOL) with palmitoyl-oleoyl phosphatidylcholine (POPC) and sphingomyelin (SPM) are considered to be important because of the occurrence of strong interactions between sphingolipids and CHOL, which lead to the formation of microdomains or rafts within biological membranes. In the present investigation, studies on the surface pressure (π)-area ( A ) measurements and fluorescence microscopic studies on monolayers of the above mentioned system have been reported. Ideality/nonideality of mixing, excess area, and free energy changes during the formation of the monolayers at different surface pressures for the mixed lipid systems were evaluated from the π– A data. Interactions were found to be repulsive at lower CHOL content, which became associative at higher CHOL content. Condensing effects of CHOL on the mixed monolayers were found. Fluorescence studies on the systems revealed similar overall results.
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