Abstract
Enthalpies of solution in water, ΔHsolo, and of sublimation, ΔHsublo, were determined experimentally for a number of crystalline N-methyl adenines: m6Ade, m26,6Ade, m9Ade, m26,9Ade, and m36,6,9Ade. Derived standard enthalpies of hydration ΔHhydro, were corrected for the calculated cavity terms ΔHcavo to yield enthalpies of interaction ΔHinto of the solutes with their hydration shells. The increments of ΔHinto per unit area of the water-accessible molecular surface SB, δΔHinto (CH3)/δSB (CH3), for the particular methyl groups: is considered to be the net effect of the gain in the energy resulting from van der Waals' interactions and of the loss in the energy due to polar interactions upon methyl substitution. It proved to vary somewhat numerically in agreement with the theoretically predicted hydration schemes of adenine. Comparison of ΔHinto/SB value for adenine with those previously determined for uracil and thymine indicates that the aminopurine moiety is less hydrated than the diketopyrimidine ring.
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