Abstract
Very often poor water solubility limits the therapeutic use of drug molecules. In order to develop strategies to overcome this handicap a basic understanding of this phenomenon is needed. In this paper Griseofulvin is used as a model substance. According to the Hess theorem the direct dissolution of Griseofulvin is replaced by a series of alternative processes which in their combination have the same starting point as well as the same endpoint as the direct dissolution. The energies associated with these alternative processes however can be determined more exactly than the dissolution energy. In cases where the measurement of an energy is impossible, e.g. the transfer energy of single molecules from the vapor phase into water, this energy is calculated by quantum chemical methods. In addition these alternative processes allow for a better understanding of the elementary steps involved in the dissolution process. The energies determined for the various alternative processes are compared with the dissolution energies as calculated by means of AMSOL. An excellent agreement can be observed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: European Journal of Pharmaceutics and Biopharmaceutics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
