Abstract
Production of tablets in pharmaceutical industry often is required to mixture the active ingredient (drug) with an inert material. Starch is shown as a good alternative material to be used as excipient. Thus, in this investigation the techniques: thermogravimetry and derivative thermogravimetry (TG/DTG), differential scanning calorimetry (DSC as well as thermomicroscopy were performed with aim to verify existence of interactions between aceclofenac (2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxalacetic) with regular maize starch and waxy maize starch. Binary and physical mixtures of aceclofenac and starch in ratios 2:1, 1:1 and 1:2 (drug:starch) studied by the instrumental techniques showed that no interactions occurs between the drug and starches in any ratio, being maintained the properties of aceclofenac.
Highlights
The excipients are inactive ingredients, these are substances they have no therapeutic activity and be used for bring stability in physicochemical properties as well as organoleptic characteristics of pharmaceutical products (Oliveira & Storpirtis, 1999)
The mixtures were made by dispersing the proportions of drug:starch in water to give a mixture with final mass of 1 g, the following proportions were used in ratios drug:starch (2:1 (c), 1:1 (d) and 1:2 (e)) for regular maize starch and (2:1 (g), 1:1 (h) and 1:2 (i) for waxy maize starch
The aceclofenac (b) is anhydrous and thermally stable up to 161 °C, after that temperature its thermal decomposition occurs in two consecutive stages of mass loss, with final residue corresponding to 0.74% of its initial mass
Summary
The excipients are inactive ingredients, these are substances they have no therapeutic activity and be used for bring stability in physicochemical properties as well as organoleptic characteristics of pharmaceutical products (Oliveira & Storpirtis, 1999). Starch is a widely used and studied excipients, because in most cases the starch does not interact with active principle formulation (Souza & Ferrão, 2006; Parisotto et al, 2005). The 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxalacetic, is a white crystalline solid, insoluble in water, commonly known as aceclofenac. It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs); chemically being a derivative of aryl acetic acid. This is a non-selective cyclooxygenase (COX) reducing metabolites and providing anti-inflammatory, analgesic and antipyretic effects. The used techniques were: thermogravimetry/derivative thermogravimetry (TG/DTG), differential scanning calorimetry (DSC) and thermomicroscopy
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