Thermo-mechanical laser ablation of soft biological tissue: modeling the micro-explosions

Abstract

Characteristics of thermo-mechanical laser ablation process are investigated using an original numerical model. In contrast with previous models, it is based on a microscopic physical model of the micro-explosion process, which combines thermodynamic behavior of tissue water with elastic response of the solid tissue components. Diffusion of dissipated heat is treated in one dimension, and the amount of thermal damage is assessed using the Arrhenius model of the protein denaturation kinetics. Influence of the pulse fluence and duration on temperature profile development, ablation threshold, and depth of thermal damage is analyzed for the case of Er:YAG laser irradiation of human skin. Influence of mechanical properties on the ablation threshold of soft tissue is predicted theoretically for the first time. In addition, feasibility of deep tissue coagulation with a repetitively pulsed Er:YAG laser is indicated from the model.