Abstract
Activators generated by electron transfer atom transfer radical polymerization (AGET ATRP) of di(ethylene glycol) methyl ether methacrylate (M(EO)2MA) was successfully conducted in miniemulsion at 65 °C. The reaction system was stable without diffusion of monomer and polymer into the aqueous phase because the monomer is water-insoluble and PM(EO)2MA becomes hydrophobic above 25 °C. The polymerization was well-controlled with a mild water-soluble reducing agent, hydrazine, yielding PM(EO)2MA homopolymer with narrow molecular weight distribution (Mw/Mn = 1.2−1.6). Using this technique, well-defined PM(EO)2MA microgels were prepared with degradable disulfide cross-linker. The microgels became magnetic after physically loading oleic acid-coated Fe3O4 nanoparticles, which could not diffuse out of the microgels due to their hydrophobicity. Thermally responsive and drug loading−releasing behavior of the magnetic microgels was studied using Rhodamine B as a model for hydrophilic drugs. The drug releasing behavior...
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