Abstract
Porcine skin is considered a de facto surrogate for human skin. However, this study shows that the mechanical characteristics of full thickness burned human skin are different from those of porcine skin. The study relies on five mechanical properties obtained from uniaxial tensile tests at loading rates relevant to surgery: two parameters of the Veronda-Westmann hyperelastic material model, ultimate tensile stress, ultimate tensile strain, and toughness of the skin samples. Univariate statistical analyses show that human and porcine skin properties are dissimilar (p < 0.01) for each loading rate. Multivariate classification involving the five mechanical properties using logistic regression can successfully separate the two skin types with a classification accuracy exceeding 95% for each loading rate individually as well as combined. The findings of this study are expected to guide the development of effective training protocols and high-fidelity simulators to train burn care providers.
Highlights
Porcine skin is considered to be anatomically and physiologically similar to human skin[1,2]. It has been used as a surrogate for human skin for evaluating mechanical characteristics under various thermomechanical loading conditions[3–5]
The univariate and multivariate statistical analyses using five mechanical properties, i.e., ultimate tensile stress, ultimate tensile strain, toughness, and two parameters of the Veronda-Westmann material model, reveal that the mechanical characteristic of full thickness burned human skin is significantly different from that of porcine skin tissues, irrespective of the three loading conditions tested in this study
These findings are consistent with previous studies that indicate that the tangent modulus of human skin is different from the porcine skin tissues, even at similar anatomical locations[13]
Summary
This study shows that the mechanical characteristics of full thickness burned human skin are different from those of porcine skin. Porcine skin is considered to be anatomically and physiologically similar to human skin[1,2]. There is no study on comparing the mechanical properties between full thickness burned human and porcine skin tissues. Such studies are important, to develop high-fidelity simulators and training protocols to train burn care providers. To develop high-fidelity simulators and training protocols to train burn care providers This is the first paper contrasting the mechanical properties of the full thickness burned human and porcine skin tissues to quantify the statistical similarity between the two. The Young’s modulus of the stratum corneum of the human and porcine
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