Abstract
Thermal wave imaging of discrete chromophores in biomaterials is reported using a phase sensitive coherent detection technique applied to recorded infrared (IR) images. We demonstrate that utilization of a periodically modulated laser source for thermal wave excitation and coherent detection applied to each pixel maybe used to compute images of the thermal wave amplitude and phase at the laser modulation frequency. The narrow-band detection technique significantly improves quality of thermal wave amplitude images. Additionally, the technique provides phase information, which may be used to assess chromophore depth in tissue. We present a theoretical analysis and computer simulations of thermal wave imaging in biological specimens. Effect of tissue optical and thermal properties on radiometric signal is discussed. Experimental application of the technique is demonstrated using tissue phantoms and an in-vivo biological model.
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