Thermal Response of Iron Oxide and Metal-Based Iron Oxide Nanoparticles for Magnetic Hyperthermia

Abstract

Magnetic nanoparticles have been extensively in the biomedical field as drug delivery agent, diagnosis of different diseases and more recently in the treatment of different types of cancer. Majority of these studies reported the use of iron oxide nanoparticles or formulation contains at least iron in most of magnetic-based nanosystems. Focus on iron oxide nanoparticles is mainly due to their superparamagnetic nature at nanoscale and other features such as higher surface to volume ratio, biocompatibility and low toxicity. For further improvement in their properties, doping with different transition metal elements is also under investigations. This chapter covers most commonly used types of iron oxide NPs, behavior with few doping metals in iron oxide nanoparticles and their synthesis protocols through different physical and chemical methods. Finally, heat generation mechanisms responsible for localized heat in tissues have been discussed.