Abstract

In the end of the second decade of 20th century, Warburg showed how cancer cells present a fermentative respiration process, related to a metabolic injury. Here, an analysis of the cell process is developed, based on its heat outflow, in order to control cancer progression. Engineering thermodynamics represents a powerful approach to develop this analysis. Indeed, the Engineering thermodynamic methods are introduced to analyse the bio-systems, in relation to heat outflow, in order to control this flux. Cells regulate their metabolisms by energy and ion flows, and the heat flux is controlled by the convective interaction with their environment. The bio-thermodynamic characteristic frequency is introduced and it is evaluated by a classical heat transfer approach. Resonance forces natural behaviours of systems, and, here, it is introduced to control both the fluxes, through the cancer membrane, and the cellular metabolic processes. Consequently, the energy available to cancer, for its growth, is controlled, too. The result, experimentally proven, consists in the decrease of rate of cancer growth.

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