Abstract
Studies using living slices of guinea pig sensorimotor cortex showed that changes in temperature from 24°C to 37°C produced stepwise increases in neuron spike frequency at two temperature zones: 27–29°C and 34–36°C. Changes in spontaneous activity were accompanied by decreases in spike amplitude at t 34°C. After cooling to 24°C, spike amplitude generally recovered completely when the temperature was increased to 32–34°C. The decrease in spike amplitude at t > 35°C could not be restored by decreasing the temperature. It is suggested that these effects are associated with the K+ permeability of neuron membranes.
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