Thermal promotion of the cobalt catalyzed intramolecular Pauson-Khand reaction — An alternative experimental protocol for cyclopentenone synthesis

Abstract

Heat alone has been found sufficient to promote intramolecular Pauson-Khand cyclizations catalyzed by high purity Co 2(CO) 8. The existence of a very narrow thermal window (e.g., 60 °C – 70 °C) for the attainment of efficient catalysis is a noteworthy characteristic of this process.