Abstract
To study the impact of target geometrical and linac operational parameters, such as target material and thickness, electron beam size, repetition rate, and mean current on the ability of the radiotherapy treatment head to deliver high-dose-rate x-ray irradiation in the context of novel linear accelerators capable of higher repetition rates/duty cycle than conventional clinical linacs. The depth dose in a water phantom without a flattening filter and heat deposition in an x-ray target by 10 MeV pulsed electron beams were calculated using the Monte-Carlo code MCNPX, and the transient temperature behavior of the target was simulated by ANSYS. Several parameters that affect both the dose distribution and temperature behavior were investigated. The target was tungsten with a thickness ranging from 0 to 3 mm and a copper heat remover layer. An electron beam with full width at half maximum (FWHM) between 0 and3 mm and mean current of 0.05-2 mA was used as the primary beam at repetition rates of 100, 200, 400, and 800 Hz. For a 10 MeV electron beam with FWHM of 1 mm, pulse length of 5 μs, by using a thin tungsten target with thickness of 0.2 mm instead of 1 mm, and by employing a high repetition rate of 800 Hz instead of 100 Hz, the maximum dose rate delivered can increase two times from 0.57 to 1.16 Gy/s. In this simple model, the limiting factor on dose rate is the copper heat remover's softening temperature, which was considered to be 500°C in our study. A high dose rate can be obtained by employing thin targets together with high repetition rate electron beams enabled by novel linac designs, whereas the benefit of thin targets is marginal at conventional repetition rates. Next generation linacs used to increase dose rate need different target designs compared to conventional linacs.
Highlights
The biological effect on both tumor and normal tissues between conventional and high dose rate radiation has been investigated for several decades but is still a topic of debate [1,2,3,4,5]
Comparing the temperatures at the start and end of each pulse, we find that copper cooling is efficient at removing heat and provides a good mechanism to reduce the target temperature, i.e., from maximum value of 1300 oC to about 400 oC
We found that due to its 2 times lower thermal conductivity compared to W, its peak temperature is about several hundred degrees higher than that of the W target under the same geometric and operational conditions
Summary
The biological effect on both tumor and normal tissues between conventional and high dose rate radiation has been investigated for several decades but is still a topic of debate [1,2,3,4,5]. 70 maintaining high kill rates in cancerous tissue [6,7,8,9,10]. This evidence, together with the desire for shorter overall treatment time, pushes for the development of systems that can deliver very high dose rates. Scanning beam hadron therapy (e.g., protons) may deliver extremely high dose rates within each pulse (>1010 Gy/s with laser driven sources) [15]
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