Abstract
Thermal interactions between normal and neoplastic tissues in mammalian species are modeled by a set of simultaneous first order nonlinear differential equations. Thermal regulation is introduced in the model, accounting for increases in the rates of metabolism, blood flow, and respiration of the normal tissues, taking under consideration the modes of reaction of the specific animals to thermal stress. The model adequately simulated the available temperature distributions data for localized hyperthermia in the rat and is also used for predictions of temperature distributions during localized and whole body hyperthermia in the rat, rabbit, swine, and dog.
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