Abstract
In the present study, by using a shell-modeling method under a rescaled mean spherical approximation (RMSA) for charged particle dispersions, we have found that the thermal structural change of sialoglycosphingolipid micelles accompanies a change of the micellar surface charge, which greatly depends on the oligosaccharide chains. Here, we treat three different types of glycosphingolipids (monosialoganglioside, disialoganglioside, and trisialoganglioside). This phenomenon is induced by a variation of temperature in the physiological temperature range 20−40 °C, which is in agreement with our recent reports showing that the thermal induced shrinkage of the hydrophilic portion of the ganglioside micelles accompanies extrusion of water. The present and previous results strongly suggest that ganglioside molecules localized in outer cell membranes are able to modulate locally both electrostatic charge potential and hydrophilicity of cell surfaces through ganglioside-rich microdomains. These functional properties...
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