Thermal design of a non-isothermal microfluidic channel for measuring thermophoresis

Abstract

Thermophoresis describes mass transport in a non-isothermal temperature field and thus provides a fundamental understanding of the behavior of colloidal particles. Various methods have been proposed for measuring the Soret coefficient, a representative value of thermophoresis. In particular, microscopic channels are an emerging method as they shorten the equilibrium time and allow direct observation of the particles. However, little emphasis has been placed on the simultaneous consideration of fluid dynamics, heat transfer, and mass transfer characteristics within the microfluidic channel, despite the simultaneous presence of natural convection and thermodiffusion phenomena. In this study, we present a novel approach to address this gap by introducing a figure of merit, which incorporates essential parameters to accurately characterize a specific cell configuration. This figure of merit allows for the identification of a reliable measurement range in a microfluidic channel with a temperature gradient, while accounting for fluid dynamics, heat transfer, and mass transfer characteristics. The proposed approach is validated through rigorous simulations and experiments, enabling an evaluation of the impact of figure of merit-derived parameters on the measurement channel. The findings from our study demonstrate that the figure of merit serves as a representative measure for stable thermophoretic measurements in a microfluidic channel. Moreover, we propose a threshold value that signifies the transition from a diffusion-dominant to a convection-dominant field.