Abstract
Objective: The aim of this work was to evaluate the stability and determine the kinetic parameters of degradation of biomarkers kaempferol and quercetin, present in the pre-formulated of the extract of Poincianella pyramidalis obtained by a spray dryer.Methods: A 23experimental design coupled with RSM was applied to evaluate and optimize the effects of processing parameters on the content of chemical markers in dry extracts by a spray dryer. Stability testing was performed to verify the influence of temperature on the degradation of kaempferol and quercetin present in the pre-formulated. The markers contents were determined by HPLC.Results: Surface response analysis showed the influence of the independent variables on the responses of the concentration kaempferol and quercentin biomarkers on the process. The variables of the inlet air temperature, flow feed rate and the adjuvant ratio presented negative responses with significant difference (p<0.05). According to the data obtained in the stability of the pre-formulated studied zero and second orders kinetics models the for degradation of the kaempferol and only second order kinetic model for the quercetin. It was also evaluated reducing the concentration of both biomarkers studied throughout the study.Conclusion: In the present study, it was observed that all independent variables of the drying process by spray dryer showed the greatest influence on the concentration of the studied markers. Two markers had a different thermal behavior compared to the different excipients studied and there was degradation of both the quercentin biomarker and kaempferol during the study period.
Highlights
IntroductionQueiroz is an arboreal species belonging to the family Fabaceae, endemic to the northeastern region of Brazil, mainly in the caatinga biome, popularly known as “catingueira”, “pau de porco”, “catinga de porco”, “pau de rato”, “mussilaba” e “catingueira-das-folhas-largas”[1]
According to the data obtained, it was verified that the operational conditions of drying by dry spray influenced the concentration of the two chemical markers studied, kaempferol and quercetin, a fact explained by the physicochemical characteristics
Statistical analysis of the experimental data showed that both the quercetin and kaempferol concentrations were significantly influenced by all the independent variables when the primary effects were evaluated, being the air inlet temperature (X1) and the carrier ratio (X2)were the most important variables in the analysis of the responses
Summary
Queiroz is an arboreal species belonging to the family Fabaceae, endemic to the northeastern region of Brazil, mainly in the caatinga biome, popularly known as “catingueira”, “pau de porco”, “catinga de porco”, “pau de rato”, “mussilaba” e “catingueira-das-folhas-largas”[1] It is used in tradicional medicine for the treatment of gastritis, colic, diarrhea, asthma, bronchitis, diabetes, as an expectorant, cicatrizant, antiinflammatory and diuretic [2,3,4,5]. Aureus e Pseudomonas aeruginosa, antioxidant, gastro protective, anti-inflammatory, antinociceptive and anthelmintic activity, which corroborates many of its traditional uses. Due to these proven pharmacological properties, this species has a great potential for the development of a herbal medicine with ample spectrum of action [11,12,13,14,15,16]
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