Abstract
AbstractThe paper reveals thermal characteristics of P.falciparum species specific proteins. These proteins determine why P. vivex species are dominant over P.falciparum in Indian geographical area. Outside human host plasmodium parasite survives in poikilothermal mosquitoes. Climatic temperature conditions greatly affect native state of P.falciparum species specific proteins in mosquitoes. Study of climatic temperature conditions in Indian geographical area reveals that Pfsd protein for Plasmodium falciparum can remain in native state between &8805;7 degree centigrade and &8804;42.6 degree centigrade temperature conditions. While their best optimum functions (activity) was noted between 25.3 degree centigrade to 33degree centigrade. Pfsd protein were found more heat susceptible for temperature minima and maxima than Pvsd proteins of P. vivex causing all time high population ratio of P.falciparum species.
Highlights
Proteins are building blocks of bio-organism and involved in diverse kind of functions
An increase can be noticed in both P. vivex and P. falciparum cases. Other than these two species of Plasmodium no other species was reported from study area
Plasmodium falciparum parasite and Pfsd proteins can survive between ≥70c and ≤42.60c temperature conditions
Summary
Proteins are building blocks of bio-organism and involved in diverse kind of functions. 2 Human malaria infects up to 500 million people and results in almost 3 million deaths per year.[3] Control of the disease is currently limited to antiparasitic drugs and mosquito control.[4] Some proteins constituting plasmodium differ at species level and show differentiating physical properties these can be termed as species differentiating proteins. This difference can be in terms of heat susceptibility. Unavailability of desired appropriate temperature (below Tmin and beyond Tmax situations) will not allow Plasmodium parasite to survive Such death of malaria parasite species will determine population load of malaria parasite among other species in any ecosystem. A study was designed to analyze thermal stability and climatic effect over Psd protein in P. falciparum in poikilothermal female Anopheles species
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