Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization.

Mona Georgescu,Ioana Stănculescu,Elena Pincu,Viorica Meltzer

doi:10.3390/ma14247715

Abstract

Nimesulide, salicylic acid and their binary mixtures were studied by differential scanning calorimetry (DSC) and Fourier Transform Infrared spectroscopy (FTIR). The study of such systems is a promising and viable approach for solving the problem of poor solubility of materials in general and drug systems in particular. All areas of human activity are inextricably linked to materials, and thus, the study presented in the paper and not reported in the literature is very important and provides useful data for those working in various fields. The eutectic mixtures were obtained by mechanosynthesis and by recrystallization from ethanol over the entire 0–1 range of molar fractions. For both situations at the molar fraction of nimesulide 0.5, the mixture has a eutectic that suggests an increase in solubility at this composition. The interactions that take place between the components were determined with the help of the excess thermodynamic functions (GE, SE, µE), which highlight the deviation from the ideality of the considered binary systems.

Highlights

Eutectics and cocrystals are a class of new materials with physical properties other than those of singular materials such as: solubility, stability, melting temperature, melting enthalpy, dissolution rate, etc. [1,2]
From the differential scanning calorimetry (DSC) data obtained for the nimesulide–salicylic acid physical mixture on first heating (Figure 2), it can be seen that all the compositions studied show an endothermic process at approximately the same temperature of 394 K, which reveals that the system is characterized by a eutectic point
The Tammann diagram starts at approximately xNIM = 0 and ends at xNIM = 1, which emphasizes that the two components of the mixture are not miscible in the solid phase

Summary

Introduction

Eutectics and cocrystals are a class of new materials with physical properties other than those of singular materials such as: solubility, stability, melting temperature, melting enthalpy, dissolution rate, etc. [1,2]. Eutectics and cocrystals are a class of new materials with physical properties other than those of singular materials such as: solubility, stability, melting temperature, melting enthalpy, dissolution rate, etc. Eutectics and cocrystals play an important role in the pharmaceutical industry due to their thermodynamic properties, which generally lead to increased solubility of poorly soluble substances [7]. Obtaining eutectics and co-crystals is a challenge for the pharmaceutical industry. The mechanical energy required for the process is obtained by grinding [10]

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