Abstract
The thermal behavior of the β-blocker anti-hypertensive drug propranolol was investigated using thermoanalytical techniques TG–DTA, DSC and the evolved gas analysis by TG–FTIR, providing information regarding thermal stability, decomposition steps, melting point and heat of fusion of the compound. The results pointed for the decomposition in a single mass loss step, after melting. DSC data revealed that cold crystallization occurred in heat–cool–heat cycles, around 165 °C. TG–FTIR presented 1-naphthol, isopropylamine and HCl as principal decomposition products. A tentative mechanism for the thermal behavior of propranolol is presented.
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