Abstract
Thermal and Lewis acid-promoted reactions of thiochalcones with (–)-dimenthyl fumarate gave two 3,4-cis-cycloadducts, 4 and 5, in good yields with 100%endo-diastereoselectivity and with a high level of diastereofacial selectivity. The major product 4 could be obtained stereochemically pure by recrystallization and this, when reduced with LiAlH4, gave the optically active diol 6. The latter was converted into the acyclic diol 8 by Raney-Ni desulphurization.
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